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| Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI | ||
| PIP2 Metabolite chebi:18348 wikidata:Q28797894 chebi:18348;chebi:18348 | ||
| PIP3 Metabolite chebi:16618 wikidata:Q28797898 chebi:16618;chebi:16618 inchikey:RQQIRMLGKSPXSE-UQPICLANSA-N | ||
| AGE-1/PI3K GeneProduct wormbase:B0334.8 age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase catalytic subunit. | ||
| 14-3-3 GeneProduct wormbase:F52D10.3 | ||
| DAF-18/PTEN GeneProduct wormbase:T07A9.6 daf-18 functions upstream to akt-1 and akt-2</br>daf-18 acts downstream of age-1 | ||
| DAF-2/InR GeneProduct wormbase:Y55D5A.5 insulin/IGF-1 pathway can diverge to regulate the timing of reproduction independently of longevity (Dillin et al., 2002a). | ||
| PDK-1/PKD1 GeneProduct wormbase:H42K12.1 | ||
| AKT-1/Akt/PKB GeneProduct wormbase:C12D8.10 | ||
| AKT-2/Akt/PKB GeneProduct wormbase:F28H6.1 | ||
| DAF-16/FOXO GeneProduct wormbase:R13H8.1 PRMT-1 specifically methylates the C terminus of the forkhead domain (FH-C) in DAF-16 blocking binding to 14-3-3 protein.</br>DAF-16 is predominantly localized in the cytoplasm as a result of inhibitory phosphorylation of Ser/Thr residues by the AKT and SGK kinases.</br>T242 is an AKT-mediated phosphorylation site in DAF-16 | ||
| JNK-1 GeneProduct wormbase:B0478.1 DAF-16 binds to JNK-1.</br>JNK-1 binds and phosphorylates DAF-16. | ||
| DAF-16/FOXO GeneProduct wormbase:R13H8.1 | ||
| JKK-1 GeneProduct wormbase:F35C8.3 | ||
| PRMT-1 GeneProduct wormbase:Y113G7B.17 | ||
| DAF-16/FOXO GeneProduct wormbase:R13H8.1 DAF-16 bound directly to PRMT-1 in in vitro pulldown assays , HA-PRMT-1 was coimmunoprecipitated with FLAG-DAF-16 only when the both proteins were coexpressed. | ||
| DAF-16/FOXO GeneProduct wormbase:R13H8.1 | ||
| RLE-1 GeneProduct wormbase:M142.6 age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase catalytic subunit.</br>RLE-1 physically interacts with DAF-16. RLE-1 C terminus is required for the interaction of RLE-1 with DAF-16. | ||
| SMK-1 GeneProduct wormbase:F41E6.4 SMK-1 was temporally and spatially colocalized with active DAF-16.</br>smk-1 RNAi does not cause a general sickness in long-lived animals but rather specifically affects IIS-regulated life span.</br>DAF-16 and SMK-1 do not directly or indirectly regulate expression or localization of one another.</br>SMK-1 specifies the longevity function of DAF-16 by affecting the efficiency of transcription of DAF-16 target genes involved in oxidative and UV stress response and innate immunity but is not required for DAF-16 regulation of heat-stress-response genes. | ||
| SGK-1 GeneProduct wormbase:W10G6.2 DAF-16 is predominantly localized in the cytoplasm as a result of inhibitory phosphorylation of Ser/Thr residues by the AKT and SGK kinases. | ||
| daf-15 GeneProduct wormbase:C10C5.6 Reduced smk-1 resulted in increased expression of daf-15 mRNA, suggesting that SMK-1 is required for the transcriptional repressor activity of DAF-16 | ||
| DAF-16/FOXO GeneProduct wormbase:R13H8.1 PRMT-1 specifically methylates the C terminus of the forkhead domain (FH-C) in DAF-16 blocking binding to 14-3-3 protein.</br>DAF-16 is predominantly localized in the cytoplasm as a result of inhibitory phosphorylation of Ser/Thr residues by the AKT and SGK kinases.</br>T242 is an AKT-mediated phosphorylation site in DAF-16 | ||
| Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps | ||
| PIP2 Metabolite chebi:18348 "" wikidata:Q28797894 chebi:18348 kegg.compound:C04637 | ||
| PIP3 Metabolite chebi:16618 "" wikidata:Q28797898 chebi:16618 inchikey:RQQIRMLGKSPXSE-UQPICLANSA-N chemspider:34980938 hmdb:HMDB0004249 kegg.compound:C05981 | ||
| AGE-1/PI3K GeneProduct ensembl:WBGene00000090 "age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase catalytic subunit." ensembl:WBGene00000090 ncbigene:174762 uniprot:Q94125 | ||
| 14-3-3 GeneProduct wormbase:F52D10.3 "" | ||
| DAF-18/PTEN GeneProduct ensembl:WBGene00000913 "daf-18 functions upstream to akt-1 and akt-2</br>daf-18 acts downstream of age-1" ensembl:WBGene00000913 ncbigene:176869 uniprot:G5EE01 | ||
| DAF-2/InR GeneProduct ensembl:WBGene00000898 "insulin/IGF-1 pathway can diverge to regulate the timing of reproduction independently of longevity (Dillin et al., 2002a)." ensembl:WBGene00000898 ncbigene:175410 uniprot:A0A0K3ARZ1;uniprot:Q968Y9;uniprot:A0A0K3ARE8;uniprot:A0A0K3AUA1;uniprot:A0A0K3AXA0;uniprot:A0A0K3AUY1 | ||
| PDK-1/PKD1 GeneProduct ensembl:WBGene00003965 "" ensembl:WBGene00003965 ncbigene:180475 uniprot:Q9Y1J3 | ||
| AKT-1/Akt/PKB GeneProduct ensembl:WBGene00000102 "" ensembl:WBGene00000102 ncbigene:179424 uniprot:Q17941 | ||
| AKT-2/Akt/PKB GeneProduct ensembl:WBGene00000103 "" ensembl:WBGene00000103 ncbigene:181524 uniprot:Q9XTG7 | ||
| DAF-16/FOXO GeneProduct ensembl:WBGene00000912 "PRMT-1 specifically methylates the C terminus of the forkhead domain (FH-C) in DAF-16 blocking binding to 14-3-3 protein.</br>DAF-16 is predominantly localized in the cytoplasm as a result of inhibitory phosphorylation of Ser/Thr residues by the AKT and SGK kinases.</br>T242 is an AKT-mediated phosphorylation site in DAF-16" ensembl:WBGene00000912 ncbigene:172981 uniprot:A0A0K3ATP5;uniprot:O16850;uniprot:A0A0K3AWG6;uniprot:A0A0K3AR95;uniprot:A0A0K3AR63 | ||
| JNK-1 GeneProduct wormbase:B0478.1 "DAF-16 binds to JNK-1.</br>JNK-1 binds and phosphorylates DAF-16." | ||
| DAF-16/FOXO GeneProduct ensembl:WBGene00000912 "" ensembl:WBGene00000912 ncbigene:172981 uniprot:A0A0K3ATP5;uniprot:O16850;uniprot:A0A0K3AWG6;uniprot:A0A0K3AR95;uniprot:A0A0K3AR63 | ||
| JKK-1 GeneProduct ensembl:WBGene00002177 "" ensembl:WBGene00002177 ncbigene:180810 uniprot:G5EDT6 | ||
| PRMT-1 GeneProduct ensembl:WBGene00013766 "" ensembl:WBGene00013766 ncbigene:180326 uniprot:Q9U2X0 | ||
| DAF-16/FOXO GeneProduct ensembl:WBGene00000912 "DAF-16 bound directly to PRMT-1 in in vitro pulldown assays , HA-PRMT-1 was coimmunoprecipitated with FLAG-DAF-16 only when the both proteins were coexpressed." ensembl:WBGene00000912 ncbigene:172981 uniprot:A0A0K3ATP5;uniprot:O16850;uniprot:A0A0K3AWG6;uniprot:A0A0K3AR95;uniprot:A0A0K3AR63 | ||
| RLE-1 GeneProduct ensembl:WBGene00010923 "age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase catalytic subunit.</br>RLE-1 physically interacts with DAF-16. RLE-1 C terminus is required for the interaction of RLE-1 with DAF-16." ensembl:WBGene00010923 ncbigene:176525 uniprot:O45962 | ||
| SMK-1 GeneProduct ensembl:WBGene00018285 "SMK-1 was temporally and spatially colocalized with active DAF-16.</br>smk-1 RNAi does not cause a general sickness in long-lived animals but rather specifically affects IIS-regulated life span.</br>DAF-16 and SMK-1 do not directly or indirectly regulate expression or localization of one another.</br>SMK-1 specifies the longevity function of DAF-16 by affecting the efficiency of transcription of DAF-16 target genes involved in oxidative and UV stress response and innate immunity but is not required for DAF-16 regulation of heat-stress-response genes." ensembl:WBGene00018285 ncbigene:179243 uniprot:H2KYN7;uniprot:H2KYN6 | ||
| SGK-1 GeneProduct ensembl:WBGene00004789 "DAF-16 is predominantly localized in the cytoplasm as a result of inhibitory phosphorylation of Ser/Thr residues by the AKT and SGK kinases." ensembl:WBGene00004789 ncbigene:181697 uniprot:Q2PJ68 | ||
| daf-15 GeneProduct ensembl:WBGene00000911 "Reduced smk-1 resulted in increased expression of daf-15 mRNA, suggesting that SMK-1 is required for the transcriptional repressor activity of DAF-16" ensembl:WBGene00000911 ncbigene:177770 uniprot:Q68TI8;uniprot:G5EEV7;uniprot:G5EF88;uniprot:S6FD39;uniprot:S6F588 |
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